University of Mohaghegh Ardabili Preventive Counseling 2783-1825 7 3 2026 09 01 Somatic Symptomatology and Generalized Anxiety in Patients with Hyperthyroidism: A Comparative Case-Control Study 71 86 4910 10.22098/jpc.2026.20724.1400 EN Mansoure Sadeghi Sefiddashti Islamic Azad University of Yazd 0009-0004-7185-2507 Afshin Ataeiyan Department of Psychiatry, Faculty of Islamic Education and Pedagogy, Islamic Azad University, Yazd Branch, Yazd, Iran. E-mail: Dr.Ataeiyan@yahoo.com Journal Article 2026 08 22 Hyperthyroidism is frequently associated with psychiatric symptoms, particularly anxiety and somatic complaints, yet the relationship between thyroid dysfunction and these psychological manifestations remains incompletely understood. This case-control study examined somatic symptoms and anxiety symptom severity in 60 hyperthyroid patients recruited from private endocrinology clinics compared to 60 demographically matched healthy controls in Yazd, Iran. Participants completed the Somatic Symptom Questionnaire (Lacourt et al., 2013) and Hamilton Anxiety Rating Scale (Hamilton, 1959), with data analyzed using discriminant function analysis, MANOVA, and Pearson correlations. Discriminant analysis revealed one significant function (Wilks' λ = 0.687, χ²(2) = 43.97, p < .001) with a canonical correlation of 0.560, accounting for 31.4% of variance in group membership. The model correctly classified 83.3% of participants overall, with 81.7% sensitivity for identifying patients and 85.0% specificity for identifying controls. Significant differences between groups were observed across nine of ten symptom dimensions (all p ≤ .002), with respiratory symptoms showing a trend (p = .014). No significant effects of gender, marital status, or age on symptom presentation were found within the patient group (all p > .05). Hyperthyroid patients exhibit significantly elevated somatic and anxiety symptoms compared to healthy individuals, independent of demographic variables. These findings highlight the necessity of integrated psychosomatic assessment and intervention in thyroid disorder management. https://jpc.uma.ac.ir/article_4910_acd352ba41be859f90a026ae986b6bdb.pdf